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EC number: 231-810-4 | CAS number: 7747-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.051 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.011 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.66 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
- PNEC value:
- 0.236 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
- PNEC value:
- 0.024 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
- PNEC value:
- 0.017 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
From a fugacity model (McKay Level III) based on key physical and chemical property parameters, it can be concluded that the ultimate compartment for distribution of EDHO is the aquatic compartment (100%). Therefore, direct and indirect exposure to the soil compartment is unlikely. EHDO is inherently biodegradable and thus has low potential for bioaccumulation. Secondary poisoning is therefore not considered as relevant route of exposure for consumers and workers. Therefore, no PNEC was calculated for oral derivation.
Based on a Koc value of 10, the mobility of EDHO in soil would be classified as very high and, in addition would not be expected to bind to sediments. Therefore, no sediment PNECs were derived.
Conclusion on classification
Data relevant for classification:
Bioaccumulation potential is expected to be minimal based on a reported log Kow of -0.32.
Degradation
EDHO is rapidly hydrolyzed to AEPD and formaldehyde, with half-lives of less than 4 hours at pH 4, 7, and 9 at 25 ºC. As a result of rapid hydrolysis and low potential for continuous input in the aquatic environment based on use patterns, potential for chronic exposure to EDHO is expected to be low.
Bioaccumulation
log Kow: -0.32. (EC method A8)
Aquatic acute toxicity
For fish: 96 h, LC50 (Rainbow trout): 130 mg/L
For aquatic invertebrates: 48 h, EC50 (Daphnia magna): 16.9 mg/L
For algae/aquatic plants: 72 h, ErC50 (Pseudokirchneriella subcapitata): 1.08 TWA mg/L
Aquatic chronic toxicity
For fish: not available
For aquatic invertebrates: 21d NOEC (Daphnia magna): 5 mg/L
For algae/aquatic plant: 72 h NOECr (Pseudokirchneriella subcapitata): 0.513 TWA mg/L
Conclusion:
CLP (2ATP):
Based on a review of the ecotoxicity values from the acute fish, daphnid, and algal studies, the key studies indicated that EDHO exhibited acute toxicity (LC/EC50) values ranging from 1.08 to 244 mg/L. Freshwater green algae were the most sensitive of the three trophic levels to EDHO. The 72-hour ErC50 based on the growth rate endpoint was 1.08 mg/L and the NOEC was 0.513 mg /L.
EDHO is classified for environmental hazards as Chronic 3 and labeled as H412: Harmful to aquatic life with long lasting effects according to the 2ndATP of the Regulation (EC) No.1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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