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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Calcium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the acute inhalation toxicity endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from Letter of Access experimental data (study with a test method similar to OECD 403) on the analogue Calcium Acetate.
GLP compliance:
no
Test type:
other: read-across from an standard acute method with an analogue

Test material

Constituent 1
Reference substance name:
Calcium di(acetate)
EC Number:
200-540-9
EC Name:
Calcium di(acetate)
Cas Number:
62-54-4
IUPAC Name:
calcium diacetate
Details on test material:
- Name of test material (as cited in study report): calcium di(acetate)
- Physical state: firmly, white powder
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
> 5.04 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Other findings:
Based on the experimental results obtained with the analogue Calcium Acetate (LC 50 for female rats > 5.6 mg/L air) and the molecular weights, the read-across approach is applied and the LC50 for substance Magnesium Acetate is calculated to be higher than 5.04 mg/L air under test conditions.

The analogue Calcium Acetate, which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is - 1.38 for Calcium Acetate and -1.38 for Magnesium Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 16600 mg/L for Magnesium Acetate at 25 ºC, and
- molecular weights which are 158.166 for Calcium Acetate and 142.40 for Magnesium Acetate.

Any other information on results incl. tables

The LC50 for substance Magnesium Acetate is calculated to be higher than 5.04 mg/L air under test conditions.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LC50 for substance Magnesium Acetate is calculated to be higher than 5.04 mg/L air under test conditions.
Executive summary:

Based on the experimental results (reported under the endpoint record 07.02.02_01 CaAc) obtained with the analogue Calcium Acetate (LC 50 for female rats > 5.6 mg/L air) and the molecular weights, the read-across approach is applied and the LC50 for substance Magnesium Acetate is calculated to be higher than 5.04 mg/L air under test conditions.