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Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: read-across from in vivo experimental test with an analogue
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Calcium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the skin irritation endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from Letter of Access experimental data (test method similar to OECD 404) on the analogue Calcium Acetate.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Calcium di(acetate)
EC Number:
200-540-9
EC Name:
Calcium di(acetate)
Cas Number:
62-54-4
IUPAC Name:
calcium diacetate
Details on test material:
- Name of test material (as cited in study report): Calciumacetat
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 24 h
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 48 h
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 24 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 48 h
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #1
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #2
Time point:
other: 9 days
Score:
0
Max. score:
0
Irritation parameter:
other: redness
Basis:
animal #3
Time point:
other: 9 days
Score:
0
Max. score:
0
Other effects:
Based on the experimental results obtained with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits skin, and applying the read-across approach, the substance Magnesium Acetate is also considered as not irritating under test conditions.

The analogue Calcium Acetate, which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is - 1.38 for Calcium Acetate and -1.38 for Magnesium Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 16600 mg/L for Magnesium Acetate at 25 ºC, and
- molecular weights which are 158.166 for Calcium Acetate and 142.40 for Magnesium Acetate.

Any other information on results incl. tables

The substance Magnesium Acetate is considered as not irritating under test conditions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance Magnesium Acetate is considered as not irritating under test conditions.
Executive summary:

Based on the experimental results (reported under the endpoint record 07.03.01_01 CaAc) with the analogue Calcium Acetate, which is considered to be not irritating for Vienna White rabbits skin, and applying the read-across approach, the substance Magnesium Acetate is also considered as not irritating under test conditions.