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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study

Data source

Reference Type:
Physical-Chemical-Activity Relationship of Organic Solvents: Effects on Na+-K+-ATPase Activity and Membrane Fluidity in Mouse Synaptosomes.
Tanii H, Huang J, Ohyashiki T, Hashimoto K
Bibliographic source:
Neurotoxicology and Teratology 16(6): 575-582

Materials and methods

Type of study / information:
Physical-chemical-activity relationship of methyl acetate (and other solvents): Effects on Na+-K+-ATPase activity and membrane fluidity in mouse synaptosomes.
Test guideline
no guideline available
Principles of method if other than guideline:
Type: other
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acetate
EC Number:
EC Name:
Methyl acetate
Cas Number:
Molecular formula:
methyl acetate
Details on test material:
analytical purity

Results and discussion

Any other information on results incl. tables

The IC50 (mM) (Na+-K+ ATPase Activity) for methyl acetate: 682
The IC12.5 (mM) (Membrane-DPH Anisotropy) for methyl acetate: 350
Log P (P=n-octanol/water partition coefficient) for methyl acetate: 0.05 (values in literature 0.18 and 0.17).

Methyl acetate had the highest IC50 (Na+-K+ ATPase Activity) and IC12.5 (Membrane-DPH Anisotropy). Therefore the toxic ability to affect membrane environment was the least among all substances tested.

Applicant's summary and conclusion