Registration Dossier
Registration Dossier
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EC number: 201-185-2 | CAS number: 79-20-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP study, a reliability of 1 is assigned.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Reference Type:
- publication
- Title:
- European Union Risk Assessment Report methyl acetate
- Author:
- European Commission - JRC - ECB
- Year:
- 2 003
- Bibliographic source:
- Office for Official Publications of the European Communities, Luxembourg
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- methyl acetate
- Details on test material:
- Formula C3H6O2
Molecular Weight 74.08 g/mol
Description: Clear, colorless liquid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- 6 hour(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 6.04 mg/l Females: 6.04 mg/l
- No. of animals per sex per dose / concentration:
- Males: 10 Females: 10
Results and discussion
Any other information on results incl. tables
Toxicokinetic examinations revealed that the blood levels of methyl acetate were below
the detection limit of 5 ppm (v/v) immediately after the end of exposure and thereafter, indicating rapid clearence of the test compund from the blood.
Applicant's summary and conclusion
- Conclusions:
- Toxicokinetic examinations revealed that the blood levels of methyl acetate were below the detection limit of 5 ppm immediately after the end of exposure and thereafter.
No bioaccumulation potential based on study results. - Executive summary:
The study reported methyl acetate concentration less than 5 ppm (v/v; < 4.6 mg/l) in rats immediately after 6 hours inhalation exposure (2,000 ppm) on the last day of a subacute study (6 hours daily, 5 days/week) and 30, 60, 120 min. as well as 18 hours later. At each time point two male rats and two female rats were sacrified to collect blood.
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