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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well documented GLP study, a reliability of 1 is assigned.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1999
Reference Type:
publication
Title:
European Union Risk Assessment Report methyl acetate
Author:
European Commission - JRC - ECB
Year:
2003
Bibliographic source:
Office for Official Publications of the European Communities, Luxembourg

Materials and methods

Objective of study:
toxicokinetics
Principles of method if other than guideline:
Method: other
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acetate
EC Number:
201-185-2
EC Name:
Methyl acetate
Cas Number:
79-20-9
Molecular formula:
C3H6O2
IUPAC Name:
methyl acetate
Details on test material:
Formula C3H6O2
Molecular Weight 74.08 g/mol
Description: Clear, colorless liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Vehicle:
not specified
Duration and frequency of treatment / exposure:
6 hour(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Males: 6.04 mg/l Females: 6.04 mg/l
No. of animals per sex per dose / concentration:
Males: 10 Females: 10

Results and discussion

Any other information on results incl. tables

Toxicokinetic examinations revealed that the blood levels of methyl acetate were below

the detection limit of 5 ppm (v/v) immediately after the end of exposure and thereafter, indicating rapid clearence of the test compund from the blood.

Applicant's summary and conclusion

Conclusions:
Toxicokinetic examinations revealed that the blood levels of methyl acetate were below the detection limit of 5 ppm immediately after the end of exposure and thereafter.
No bioaccumulation potential based on study results.
Executive summary:

The study reported methyl acetate concentration less than 5 ppm (v/v; < 4.6 mg/l) in rats immediately after 6 hours inhalation exposure (2,000 ppm) on the last day of a subacute study (6 hours daily, 5 days/week) and 30, 60, 120 min. as well as 18 hours later. At each time point two male rats and two female rats were sacrified to collect blood.