Registration Dossier
Registration Dossier
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EC number: 202-849-4 | CAS number: 100-41-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Reference Type:
- publication
- Title:
- Toxicological studies of certain alkylated benzenes.
- Author:
- Wolf, M.A.; Rowe, V.K.; McCollister, D.D.; Hollingworth, R.L.; Oyen, F.
- Year:
- 1 956
- Bibliographic source:
- AMA Arch. Ind. Health. 14:387-398.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline available
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethyl benzene
- Physical state: liquid
- Analytical purity: 98%+
-Specific gravity at 20ºC: 0.86
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in-house
- Age at study initiation: not specified in the report
- Weight at study initiation: 175-250 g
- Fasting period before study: not specified in the report
- Housing: not specified in the report
- Diet (e.g. ad libitum): not specified in the report
- Water (e.g. ad libitum): not specified in the report
- Acclimation period: not specified in the report
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified in the report
- Humidity (%): not specified in the report
- Air changes (per hr): not specified in the report
- Photoperiod (hrs dark / hrs light): not specified in the report
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: either as undiluted material or as an olive oil or corn oil solution emulsified with a 5-10 % aqueous solution of gum arabic
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: The total volume administered was never greater than 7 cc
- Doses:
- not specified in the report
- No. of animals per sex per dose:
- total 57 animals were used
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified in the report
- Necropsy of survivors performed: not specified in the report - Statistics:
- not specified in the report
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 500 mg/kg bw
- Mortality:
- not specified in the report
- Clinical signs:
- other: not specified in the report
- Gross pathology:
- not specified in the report
- Other findings:
- not specified in the report
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value of Ethylbenzene in rats was estimated to be 3.5gm/kg (3500mg/kg).
- Executive summary:
The acute toxicity study of Ethylbenzene was evaluated in rats and observed for 2 weeks. The LD50 value of Ethylbenzene in rats was estimated to be 3.5gm/kg (3500mg/kg) and was not classifiable according to EU
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