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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1956
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1956
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes.
Author:
Wolf, M.A.; Rowe, V.K.; McCollister, D.D.; Hollingworth, R.L.; Oyen, F.
Year:
1956
Bibliographic source:
AMA Arch. Ind. Health. 14:387-398.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline available
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene
Details on test material:
- Name of test material (as cited in study report): Ethyl benzene
- Physical state: liquid
- Analytical purity: 98%+
-Specific gravity at 20ºC: 0.86

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: in-house
- Age at study initiation: not specified in the report
- Weight at study initiation: 175-250 g
- Fasting period before study: not specified in the report
- Housing: not specified in the report
- Diet (e.g. ad libitum): not specified in the report
- Water (e.g. ad libitum): not specified in the report
- Acclimation period: not specified in the report

ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified in the report
- Humidity (%): not specified in the report
- Air changes (per hr): not specified in the report
- Photoperiod (hrs dark / hrs light): not specified in the report

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: either as undiluted material or as an olive oil or corn oil solution emulsified with a 5-10 % aqueous solution of gum arabic
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: The total volume administered was never greater than 7 cc
Doses:
not specified in the report
No. of animals per sex per dose:
total 57 animals were used
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified in the report
- Necropsy of survivors performed: not specified in the report
Statistics:
not specified in the report

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 3 500 mg/kg bw
Mortality:
not specified in the report
Clinical signs:
not specified in the report
Body weight:
not specified in the report
Gross pathology:
not specified in the report
Other findings:
not specified in the report

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of Ethylbenzene in rats was estimated to be 3.5gm/kg (3500mg/kg).
Executive summary:

The acute toxicity study of Ethylbenzene was evaluated in rats and observed for 2 weeks. The LD50 value of Ethylbenzene in rats was estimated to be 3.5gm/kg (3500mg/kg) and was not classifiable according to EU

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