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EC number: 202-849-4 | CAS number: 100-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental investigation, but study well documented, meeting generally accepted scientific principles, acceptable for assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensory irritation caused by various industrial airborne chemicals.
- Author:
- De Ceaurriz, J.C.; Micillino, J. ; Bonnet, P. ; Guenier, J.
- Year:
- 1 981
- Bibliographic source:
- Toxicol. Lett. 9:137-144.
Materials and methods
- Principles of method if other than guideline:
- This study was carried out to investigate the sensory irritation potential of a series of airborne chemicals including ethylbenzene. Relative potency was evaluated by determining the RD50 (concentration associated with a 50% reduction in reflwx respiratory rate).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethylbenzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Swiss OF1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA CREDO Laboratories (France)
- Weight at study initiation: 25 ± 2 g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Groups of 6 male Swiss OF1 mice (weighing 25 g +-2) were used at each of at least 4 different concentrations for each dose level for a period of 5 minutes. The animals were exposed head only enclosed in whole body plethysmographs. A control reading was obtained prior to exposure. The air concentrations of ethylbenzene were monitored by gas chromatography. During exposure the respiratory rate decreased and the maximum % decrease from control values was calculated.
The dose response relationship was obtained by plotting the maximum decrease in respiratory rate against log conc. The dose response curves were obtained by using a least squares linear regression analysis. Each curve showed a linear relationship between log conc and decrease in respiratory rate wich was used to calculate the RD50. - Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: RD50
- Effect level:
- 1 432 ppm
- Mortality:
- no data
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The RD50 for ethylbenzene was found to be 1432 ppm (6.2 mg/l assuming a conversion factor for EB of 1 ppm = 0.00434 mg/l).
- Executive summary:
This study was carried out to investigate the sensory irritation potential of a series of airborne chemicals including ethylbenzene. Relative potency was evaluated by determining the RD50 (concentration associated with a 50% reduction in reflwx respiratory rate).
Groups of 6 male Swiss OF1 mice (weighing 25 g +-2) were used at each of at least 4 different concentrations for each dose level for a period of 5 minutes. The animals were exposed head only enclosed in whole body plethysmographs. A control reading was obtained prior to exposure. The air concentrations of ethylbenzene were monitored by gas chromatography. During exposure the respiratory rate decreased and the maximum % decrease from control values was calculated. The dose response relationship was obtained by plotting the maximum decrease in respiratory rate against log conc. The dose response curves were obtained by using a least squares linear regression analysis. Each curve showed a linear relationship between log conc and decrease in respiratory rate wich was used to calculate the RD50.
The RD50 for ethylbenzene was found to be 1432 ppm (6.2 mg/l assuming a conversion factor for EB of 1 ppm = 0.00434 mg/l).
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