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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure not according to a defined method, but data reproducible and scientifically acceptable
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1949
Reference Type:
publication
Title:
Range finding toxicity data: List VI
Author:
Smyth, Jr. H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C. and Striegel, J.A.
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23:95-107

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene
Details on test material:
- Name of test material (as cited in study report): Ethylbenzene
- Physical state: liquid
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: 719
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
not specified in the report

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
not specified in the report
Duration of treatment / exposure:
24 hour(s)
Observation period:
not specified in the report
Number of animals:
5
Details on study design:
The skin irritation method employed in this study is non-standard. The irritation is based on the severest reaction which occurs on the shorn ventral skin of 5 albino rabbits 24 hours after the uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10).

Results and discussion

In vivo

Results
Irritation parameter:
other: non-standard skin irritation
Time point:
other: 24 hr
Score:
4
Max. score:
6
Remarks on result:
other: Uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10)
Irritant / corrosive response data:
not specified in the report
Other effects:
not specified in the report

Any other information on results incl. tables

No data was available.

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Ethyl benzene is considered a moderate skin irritant (grade 4).
Executive summary:

Ethylbenzene was evaluated for dermal irritation in rabbits and based under the conditions of the study was graded as Grade 4 (moderate skin irritant).

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