Registration Dossier
Registration Dossier
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EC number: 202-849-4 | CAS number: 100-41-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure not according to a defined method, but data reproducible and scientifically acceptable
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth, Jr. H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C. and Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23:95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethylbenzene
- Physical state: liquid
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: 719
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified in the report
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- not specified in the report
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- not specified in the report
- Number of animals:
- 5
- Details on study design:
- The skin irritation method employed in this study is non-standard. The irritation is based on the severest reaction which occurs on the shorn ventral skin of 5 albino rabbits 24 hours after the uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10).
Results and discussion
In vivo
Results
- Irritation parameter:
- other: non-standard skin irritation
- Time point:
- other: 24 hr
- Score:
- 4
- Max. score:
- 6
- Remarks on result:
- other: Uncovered application of 0.01 ml of undiluted test material (grades 1-6) or solutions in water, propylene glycol or acetone (grades 7-10)
- Irritant / corrosive response data:
- not specified in the report
- Other effects:
- not specified in the report
Any other information on results incl. tables
No data was available.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Ethyl benzene is considered a moderate skin irritant (grade 4).
- Executive summary:
Ethylbenzene was evaluated for dermal irritation in rabbits and based under the conditions of the study was graded as Grade 4 (moderate skin irritant).
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