Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Insufficient study detail to assign a reliable Klimisch rating.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2003
Report Date:
2003

Materials and methods

Principles of method if other than guideline:
Insufficient study detail.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: Liquid at room temperature.
Details on test material:
As per IUCLID5 Sections 1.1, 1.2. and 1.4.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
Exposure was for 4 hours.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 4 h
Concentrations:
240 mg/m3 (saturated vapor concentration) or approximately 26 ppm.
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 240 mg/m³ air
Exp. duration:
4 h
Mortality:
No data, assume none.
Clinical signs:
other: "No signs of intoxication were observed after exposure."
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Inhalation exposure of rats to a saturated vapour concentration of 2,3-epoxypropyl neodecanoate of approximately 240 mg/m3 (26 ppm) resulted in no mortalities. Therefore, the acute 4 hr LC50 value for 2,3-epoxypropyl neodecanoate is > 240 mg/m3 (26 ppm).
Executive summary:

The acute 4 hr inhalation LC50 value of 2,3 -epoxypropyl neodecanoate to rats was > 240 mg/m3 (26 ppm).