Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-430-6 | CAS number: 95-54-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- 1. Very limited information on methodology and results reported. 2. Non-standard method for acute toxicity testing.
Data source
Reference
- Reference Type:
- publication
- Title:
- Dominant lethal mutagenicity study on hair dyes
- Author:
- Burnett C, Loehr R, Corbett J
- Year:
- 1 977
- Bibliographic source:
- Journal of Toxicology and Environmental Health 2, 657-662
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- o-phenylenediamine
- EC Number:
- 202-430-6
- EC Name:
- o-phenylenediamine
- Cas Number:
- 95-54-5
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,2-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 10% DMSO
- No. of animals per sex per dose:
- 5 per group
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 516 mg/kg bw
- 95% CL:
- 474 - 560
Applicant's summary and conclusion
- Conclusions:
- LD50 (rat): 516 mg/kg
- Executive summary:
The LD50 in the rat after ip injection was reported as 516 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
