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EC number: 213-139-9 | CAS number: 926-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl(propyl)amine
- EC Number:
- 213-139-9
- EC Name:
- Dimethyl(propyl)amine
- Cas Number:
- 926-63-6
- Molecular formula:
- C5H13N
- IUPAC Name:
- dimethyl(propyl)amine
Constituent 1
- Specific details on test material used for the study:
- - Lot/batch No.: K322/1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain as cited in study report: chbb: thom (SPF)
- Source: Boehringer Ingelheim Pharma KG
- Age at study initiation: young adult animals
- Weight at study initiation: 200-300 g
- Housing: single housing in stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiet (Provimi Kliba SA, Kaiseraugst, Switzerland), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark/hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 cm2
- % coverage: 10
- Type of wrap if used: semi-occlusive dressing consisting of four layers absorbent gauze and Fixomull stretch (adhesive fleece)
- Fur was clipped 24 hrs before study begin
REMOVAL OF TEST SUBSTANCE
- Washing: after removal of the dressing, the application site was rinsed with warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Application volume: 2.78 mL/kg bw
- Density: 0.719 g/mL - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- DURATION OF OBSERVATION PERIOD
14 days
FREQUENCY OF OBSERVATIONS FOR MOTALITY AND CLINICAL SYMPTOMS
A check for any dead or moribund animal was made twice each workday and once on Saturdays, Sundays and on public holidays. Clinical symptoms were recorded several times on the day of administration and at least once per workday thereafter.
FREQUENCY OF WEIGHING
Individual body weights were recorded shortly before exposure (day 0), weekly thereafter, and finally before the sacrifice of the animals at the end of the observation period.
SKIN FINDINGS
Individual examination of skin was done between 3 to 60 minutes after removal of the dressing (i.e., day 1), weekly thereafter, and at the end of the observation period. The findings were scored according to the Draize scoring system (Draize, JH, Appraisal of the safety of chemicals in foods, drugs and cosmetics. The association of food and drug officials of the United States Austin,Texas, 1959).
NECROPSY
At the end of the observation period the surviving animals were sacrificed with CO2-inhalation and were subjected to gross pathological examination as well as the animal which died before. - Statistics:
- The binomial test (Snedecor GW and Cochran WG, Statistical methods, 8th ed., Iowa State University Press/Ames, 1989) was used.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occurred.
- Clinical signs:
- other: Neither clinical symptoms of toxicity nor local skin reactions could be evidenced.
- Gross pathology:
- At necropsy, gross pathology revealed no abnormalities.
Any other information on results incl. tables
Body weight data:
Animals |
Individual body weights (g) |
|||
Sex |
Number |
Day 0 |
Day 7 |
Day 13 |
Males |
1 |
279 |
304 |
333 |
2 |
276 |
296 |
322 |
|
3 |
280 |
308 |
346 |
|
4 |
276 |
298 |
328 |
|
5 |
276 |
301 |
329 |
|
Females |
1 |
229 |
219 |
226 |
2 |
229 |
241 |
248 |
|
3 |
230 |
225 |
250 |
|
4 |
227 |
224 |
241 |
|
5 |
234 |
234 |
240 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was tested for acute dermal toxicity in rats in a limit test conducted according to the OECD TG 402 (1987). The study conduct was GLP conform. The test item was applied at 2000 mg/kg bw onto the clipped skin of each of 5 male and 5 female animals, under semi-occlusive conditions for 24 hours.
Neither mortality nor clinical symptoms of toxicity were observed. No skin reactions were noticed. Body weights and body weight gain were as expected, and at necropsy, gross pathology revealed no abnormalities. Therefore the LD50 for acute dermal toxicity was > 2000 mg/kg bw for male and female rats.
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