Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
carcinogenicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source with no methodological information. Read across from dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)

Data source

Reference
Reference Type:
review article or handbook
Title:
Ecological and Toxicological Aspects of Mono and Disubstituted Methyl-, Butyl-, Octyl-, and Dodecyltin Compounds - Update 2002
Author:
Summer K.H., Klein, D. & Greim, H.
Year:
2003
Bibliographic source:
Primary Source: Mosinger M., Centre D’Explotations et de Recherches Medicales, Marseille (1975). Final Report Advastab TM 181 FS (Cincinnati-Milacron)

Materials and methods

Principles of method if other than guideline:
No methodological information available.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
Two years
Doses / concentrations
Remarks:
Doses / Concentrations:
100 ppm
Basis:

No. of animals per sex per dose:
Twenty

Results and discussion

Results of examinations

Details on results:
dimethyltin dichloride: methyltin trichloride (72:28% mixture)

Applicant's summary and conclusion

Conclusions:
No malignant tumours were reported in in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.
Executive summary:

Twenty male and female rats were dose with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for 2 years in a feeding study. No further information is available.

No malignant tumours were reported in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.