Registration Dossier
Registration Dossier
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EC number: 212-039-2 | CAS number: 753-73-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source with no methodological information. Read across from dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Ecological and Toxicological Aspects of Mono and Disubstituted Methyl-, Butyl-, Octyl-, and Dodecyltin Compounds - Update 2002
- Author:
- Summer K.H., Klein, D. & Greim, H.
- Year:
- 2 003
- Bibliographic source:
- Primary Source: Mosinger M., Centre D’Explotations et de Recherches Medicales, Marseille (1975). Final Report Advastab TM 181 FS (Cincinnati-Milacron)
Materials and methods
- Principles of method if other than guideline:
- No methodological information available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate)
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- Two years
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 ppm
Basis:
- No. of animals per sex per dose:
- Twenty
Results and discussion
Results of examinations
- Details on results:
- dimethyltin dichloride: methyltin trichloride (72:28% mixture)
Applicant's summary and conclusion
- Conclusions:
- No malignant tumours were reported in in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.
- Executive summary:
Twenty male and female rats were dose with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for 2 years in a feeding study. No further information is available.
No malignant tumours were reported in animals dosed with 100 ppm dimethyltin bis(2-ethylhexylthioglycolate) + monomethyltin tris(2-ethylhexylthioglycolate) for two years as compared to 8/164 in control animals.
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