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EC number: 203-113-5
CAS number: 103-45-7
Phenylethyl acetate was investigated for the potential to induce reverse
mutations in bacterial tester strains in the Ames test. No positive
results were obtained in plate incorporation or pre-incubation assays
with or without the use of metabolic activation.
The read-across substance benzyl acetate was considered to be mutagenic
in the presence of metabolic activation in both the mouse and human
lymphoma assays. Benzyl acetate showed a marginal
induction of structural aberrations, predominantly chromatid exchanges
but only at the highest dose in 24 hour continuous treatment without S9
mix. Because there was no structural aberration
induction with any other treatment and the dose range used, it was still
considered to be negative.
Benzyl acetate was investigated for its ability to unscheduled DNA
synthesis in the hepatocytes of Fischer-344 rats following in vivo
treatment. Rats received a single dose of the test substance dissolved
or suspended in corn oil administered by oral gavage at dose levels of
5, 200 and 1000 mg/kg bw. The responses were examined at the 2 and 12
hour timepoints. Administration of benzyl acetate did not result in any
increase in the numbers of net grains or the proportion of cells in
Justification for selection of genetic toxicity endpoint
Higher tier study reporting a negative response
Short description of key information:
An Ames test is available for phenyl ethyl acetate. Studies of chromosomal aberration in vitro, mammalian cell mutation in vitro and UDS in vivo are available for the read-across substance benzyl acetate
Endpoint Conclusion: No adverse effect observed (negative)
No classification is proposed for genetic toxicity. A positive result
obtained in vitro with the read-across substance benzyl acetate was not
replicated in a study in vivo. Other studies in vitro with phenyl ethyl
acetate and benzyl acetate do not indicate a genotoxic hazard.
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