Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 446-630-3
CAS number: 181587-01-9
The substance is not readily biodegradable in accordance with the
definition given in the OECD Guidelines for the Testing of Chemicals. Simulation
studies in soil conducted according to GLP and EU Council Directive
91/414/EEC as amended by Commission Directive 95/36/EC, and US EPA
Subdivision N Pesticide guideline 162-1, obtained DT50 values in five
different soils ranging from 22.4 - 236.4 days (recalculated to 12 °C).
Therefore, in a worst-case approach, the substance meets the vP
criterion (T1/2 > 180 days in soil) based on REACH legislation Annex
XIII in soil. Hence, the substance is vP/P.
Therefore, the substance does meet the P criterion and
is considered as persistant (P) or very persistant (vP).
Results of a study reveal that ethiprole does not show significant
accumulation in aquatic organisms. Due to rapid depuration, the
potential for biomagnification through the food chain is low as
indicated by a study according to OECD 305 B and GLP. The depuration
half-life of the substance in fish ranged from 31 to 35.5 h and its
bioconcentration factor (BCF) was found to range from 8.92 to 10.24.
Thus, the substance has a low potential for bioaccumulation in fish. The
log Kow of the substance with a value of 2.9 is below 4.5.
The available information indicates that the substance has a very low
potential for bioconcentration and will not accumulate in any
significant levels in aquatic organisms.
Therefore, the substance does not meet the B criterion.
From the ecotoxicity perspective the toxicity criterion is met for
the substance with a lowest NOEC of 0.01 mg/L (long term fish) being at
the ecologically relevant NOEC triggers of 0.01 mg/L.
substance is classified for specific target organ toxicity after
repeated exposure (STOT RE 2) based on the effects on liver and thyroid
gland in a sub-chronic toxicity study with rats.
Therefore, the substance is T.
Summary and overall
conclusions on PBT or vPvB properties
the assessment described in the subsections above the submission
substance is not a PBT / vPvB substance.
to Annex XIII of the REACH Regulation (EC) No 1907/2006, a PBT substance
has to meet all three of the criteria for persistence, bioaccumulation
and toxicity, as listed in part 1 of Annex XIII, and a vPvB substance
has to meet all criteria for persistence and bioaccumulation, as listed
in part 2 of Annex XIII. Based on the relevant data provided and
discussed, the substance is not identified as PBT or as a vPvB substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again