Registration Dossier
Registration Dossier
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EC number: 446-630-3 | CAS number: 181587-01-9
Endpoint summary
Administrative data
Description of key information
Additional information
The main abiotic pathway for degradation of the target compound is photodegradation in water with a half-life of 1.3 days, while hydrolysis plays no role in the degradation of ethiprole (DT50 = 121 days at pH 9 and 25 °C).
Ethiprole is not readily biodegradable as seen in an OECD 301B test, which resulted in 18% biodegradation (ThCO2) after 28 days. A rapid transformation of the substance was demonstrated in two simulation studies with different water/sediment systems. In both studies the substance was rapidly transferred from water to sediment, half-lives of the target compound ranged from 4 to 13.5 days (8.5 to 28.7 days, recalculated to 12 °C) in the water/sediment systems.
Three different simulation studies investigating the degradation in a total of five soil types (clay loam, sandy loam, loam, sand, and silt loam). The DT50 values in different soils ranged from 10.5 to 71 days (22.4 to 236.4 days, recalculated to 12 °C). The target compound demonstrated to be very persistent (T1/2 > 180 days based on Annex XIII criteria of REACH regulation EC No 1907/2006) in one soil type (silt loam, DT50 236.4 days). Photolysis in soil showed a half-life of 34 days in artificial sunlight and 48 days in permanent darkness. However, the log Koc value of 2.1 indicates a low potential of the substance for adsorption to soil and sediment particles. Furthermore, the moderate water solubility (9.2 mg/L), and the low vapour pressure (9.1E-08 Pa), indicate that the main target compartment for the substance will be the aquatic compartment. The low vapour pressure of ethiprole (9.1E-08 Pa) indicates that the compound is not volatile. Therefore, any risk of long-range transport by or accumulation in the air is very unlikely, for the substance and it is concluded that the substance will not accumulate in air and will not be transported through the vapour phase into other environmental compartments in relevant amounts. Therefore, air is not a likely route of environmental exposure and no accumulation and subsequent deposition of the substance is to be expected.
The bioconcentration factor (BCF) of the substance in fish was found to range from 8.92 to 10.24 and the depuration half-life was 31 to 35.5 h. Hence, the substance exhibits a low potential for bioaccumulation in fish.
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