Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 Apr 1998 - 9 Aug 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Qualifier:
according to guideline
Guideline:
other: Directive 94/37/EC, Annex I, §2.6 and 2.7
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
9.2 mg/L
Temp.:
20 °C
pH:
>= 6.3 - <= 7
Remarks on result:
other: Influence of pH= 4.6 - 9 being insignificant

The impurity profile of the test item recovered from the glass beads examined by HPLC no significant changes were detected in the size or number of peaks observed. The HPLC analysis did not show a significant decrease of the product content (< 3%).

The calibration curve fits over the whole working range from 0.56 – 2.8 g/L (5 calibration levels)

with r²=0.99999 (quadratic fit).

 

Sample

Volume collected [mL]

pH

Concentration [mg/L]

Run 1:Flow rate 0.5 mL/min (30 mL/h, 20.05°C)

1

1

 

9.311

2

25

6.98

 

3

1

 

9.288

4

25

6.78

 

5

1

 

9.251

6

25

6.81

 

7

1

 

9.251

8

25

6.80

 

9

1

 

9.230

10

25

6.49

 

11

1

 

9.229

12

25

6.54

 

13

1

 

 

14

25

6.39

 

Mean value samples 1-14

9.26

Run 2:Flow rate 0.3 mL/min (18 mL/h, T=19.85 °C

1

1

 

9.135

2

25

6.75

 

3

1

 

9.093

4

25

6.67

 

5

1

 

9.108

6

25

6.32

 

7

1

 

9.015

8

25

6.57

 

9

1

 

9.104

10

25

6.61

 

11

1

 

9.203

12

25

6.43

 

Mean value samples 1 - 12

9.11

 

Description of key information

9.2 mg/L at 20 °C, pH=6.3-7.0

Key value for chemical safety assessment

Water solubility:
9.2 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined using column elution method according to EPA OPPTS 830.7840. The solubility was not studied at different pH values since the substance did not show significant differences of values at three pHs (pH= 4.6 - 9), as determined in the preliminary test.