Registration Dossier
Registration Dossier
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EC number: 247-557-8 | CAS number: 26264-06-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Principles of method if other than guideline:
- The purpose of the study was to determine the toxicity of five purehomologues of LAS to the activated sludge of a treatment plant basically operating on domestic sewage. A contact time of 3 hours instead of 15 minutes was chosen to better simulate the real residence time used in wastewater treatment plants (4-6 hours).
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge
- Test type:
- other: aquatic
- Limit test:
- no
- Total exposure duration:
- 3 h
- Details on test conditions:
- Activated sludges:The activated sludge from the aeration pond of the sewage treatment plant of Estepona. This sludge has a carbon content of 40% and moisture level of 82%.
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 500 - <= 723 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- Acute toxicity to Microorganism (activated sludge): 3hr-EC50 is 500-723 mg/L (nominal).
- Results with reference substance (positive control):
- The 3-hour EC50 range for the reference substance (3,5-dichlorophenol) ranged from 20- 30 mg/L, within the valid range of 5-30 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- Acute toxicity to Microorganism (activated sludge): 3hr-EC50 is 500-723 mg/L (nominal).
Reference
Description of key information
Acute toxicity to Microorganism (activated sludge): 3hr-EC50 is 500-723 mg/L (nominal).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 500 mg/L
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Acute toxicity to Microorganism (activated sludge): 3hr-EC50 is 500-723 mg/L (nominal).
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