Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-557-8 | CAS number: 26264-06-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Human Repeat Insult Patch Test
- Principles of method if other than guideline:
- Human Repeat Insult Patch Test
Method:LAS was applied at 0.10% (w/v) on the upper arms of volunteers, under occlusive patch conditions. Test material was applied for 24 hours, 3 times a week, for 3 weeks during the induction period. After a 14-17-day rest, a 24- hour challenge patch was applied on the original and alternate arm sites. - GLP compliance:
- not specified
Test material
- Reference substance name:
- C12-LAS
- IUPAC Name:
- C12-LAS
- Details on test material:
- LAS; activity: 30.0%
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- confirmed, but no further information available
- Subjects:
- 95 volunteers were treated with LAS at 0.10% (w/v) on the upper arms, under occlusive patch conditions.
- Route of administration:
- dermal
- Details on study design:
- LAS was applied at 0.10% (w/v) on the upper arms of volunteers, under occlusive patch conditions. Test material was applied for 24 hours, 3 times a
week, for 3 weeks during the induction period. After a 14-17-day rest, a 24- hour challenge patch was applied on the original and alternate arm sites.
Results and discussion
- Results of examinations:
- There was no evidence of skin sensitization on the 95 subjects who completed the test.
Applicant's summary and conclusion
- Conclusions:
- 95 volunteers were treated with LAS at 0.10% (w/v) on the upper arms, under occlusive patch conditions. Test material was applied for 24 hours, 3 times a week, for 3 weeks during the induction period. After a 14- to 17-day rest, a 24-hour challenge patch was applied on the original and alternate arm sites.
There was no evidence of skin sensitisation on the 95 subjects who completed the test. - Executive summary:
95 volunteers were treated with LAS at 0.10% (w/v) on the upper arms, under occlusive patch conditions. Test material was applied for 24 hours, 3 times a week, for 3 weeks during the induction period. After a 14- to 17-day rest, a 24-hour challenge patch was applied on the original and alternate arm sites.
There was no evidence of skin sensitisation on the 95 subjects who completed the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
