Registration Dossier

Diss Factsheets

Ecotoxicological information

Biotransformation and kinetics

Currently viewing:

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Fish (Cyprinus carpio 34.6 g) were exposed to combinations of LAS, polyoxyethylene and sorbitan monooleate to assess the influence of these substances on the uptake of LAS. Exposure period was 3 h. Exposure concentration was 1 x 10-5 M LAS. LSC was used for tissue specific analysis, HPLC was used for measurement of gill adsorption. Dechlorinated tap water, filtered over active carbon; hardness 63 mg/L CaCO3; water/fish ratio: 0.14 g/L; no feeding during experiment
GLP compliance:
not specified
Type of medium:
aquatic

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dodecylbenzenesulfonate
EC Number:
246-680-4
EC Name:
Sodium dodecylbenzenesulfonate
Cas Number:
25155-30-0
Molecular formula:
C18H30NaO3S
IUPAC Name:
sodium dodecylbenzenesulfonate
Test material form:
solid: compact
Details on test material:
Labelled linear LAS, isomer distribution not specified. (CAS #25155-30-3)
Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Results and discussion

Any other information on results incl. tables

Concentration factors for specific tissues (measured by LSC) were for blood 4.2, hepatopancreas 4.0, spleen 1.0, kidney 3.3, heart 1.7, brain 0.6, muscles 0.2, gill 11, gall bladder 21. Adsorption of LAS to gills (Cgill/Cwater), measured by HPLC, isomer specific: 2-phenyl 16; 3-phenyl 5.4; 4-phenyl, 2.6; 5- and 6-phenyl 1.9. C12-LAS associated radiolabel is taken up by gills rapidly. It reaches the highest body level in the gall bladder after only three hours. The adsorption to the gills is related to the phenyl-substitution of the alkane. The closer the benzenesulfonate-group is attached to the terminal carbon atom of the alkyl chain, the higher the adsorption to the gills. As the gills are an important organ in the uptake of xenobiotic compounds, it seems reasonable to expect that those isomers which sorb strongly to the gills will also be taken up preferentially.

Applicant's summary and conclusion

Conclusions:
Concentration factors for specific tissues (measured by LSC) were for blood 4.2, hepatopancreas 4.0, spleen 1.0, kidney 3.3, heart 1.7, brain 0.6, muscles 0.2, gill 11, gall bladder 21. Adsorption of LAS to gills (Cgill/Cwater), measured by HPLC, isomer specific: 2-phenyl 16; 3-phenyl 5.4; 4-phenyl,
2.6; 5- and 6-phenyl 1.9. C12-LAS associated radiolabel is taken up by gills rapidly. It reaches the highest body level in the gall bladder after only three hours. The adsorption to the gills is related to the phenyl-substitution of the alkane. The closer the benzenesulfonate-group is attached to the terminal carbon atom of the alkyl chain, the higher the adsorption to the gills. As the gills are an important organ in the uptake of xenobiotic compounds, it seems reasonable to expect that those isomers which sorb strongly to the gills will also be taken up preferentially.

Categories Display