Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study

Data source

Reference
Reference Type:
publication
Title:
IPCS, International Programme on Chemical Safety, Poisons Information Monograph 980, Thiodiglycol
Author:
WHO
Year:
2001
Bibliographic source:
[http://www.inchem.org/documents/pims/chemical/pim980.htm]

Materials and methods

Type of study / information:
Type of experience: Human

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethane-1,2-diol
EC Number:
203-473-3
EC Name:
Ethane-1,2-diol
Cas Number:
107-21-1
Molecular formula:
C2H6O2
IUPAC Name:
ethylene glycol

Results and discussion

Results:
Based on the structural similarity to ethylene glycol, thiodiglycol may produce depression of the central nervous system, metabolic acidosis and renal failure in severe intoxication.

Applicant's summary and conclusion

Conclusions:
Thiodiglycol may produce depression of the central nervous system, metabolic acidosis and renal failure in severe intoxication.
Executive summary:

Based on the structural similarity to ethylene glycol, thiodiglycol may produce depression of the central nervous system, metabolic acidosis and renal failure in severe intoxication.