Thiodiglycol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days [but no deaths expected in the 2nd week])

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Annex of the Guideline 403

Deviations:

no

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

1

Reference substance name:

Thiodiglycol

EC Number:

203-874-3

EC Name:

Thiodiglycol

Cas Number:

111-48-8

Molecular formula:

C4H10O2S

IUPAC Name:

2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

mean weight: 180 g
No further details

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: air

Details on inhalation exposure:

Rats exposed for 8 h to a vapour saturated atmosphere.
Vapours generated by bubbling 200 l/h air at 20°C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

Saturated vapour.

No. of animals per sex per dose:

6 males and 6 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: observations performed (no details), body weight determined at day 0 and 7
- Necropsy of survivors performed: yes, 7 days after inhalation exposure

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: saturated vapour

Exp. duration:

8 h

Remarks on result:

other: IHT

Mortality:

No mortality

Clinical signs:

other: Symptoms: Immediately after the start of exposure, the animals showed attempts to escape, after 1 hour an irritation (slight irritation; BASF AG, 1966) of mucous membranes (BASF AG, 2004; no further details). No clinical signs and findings from the first

Body weight:

No data

Gross pathology:

Necropsy: 3 out of 12 animals showed chronic bronchitis. This finding is judged to be caused by the breeding and housing conditions and not to represent an exposure related effect. No macroscopic pathologic abnormalities were noted in the other animals.

Other findings:

No

Applicant's summary and conclusion

Conclusions:

No mortality in male and female rats exposed to saturated vapour at 20°C for 8 h.

Executive summary:

Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days [but no deaths expected in the 2nd week]).

Six male and 6 female rats were exposed for 8 h to saturated vapour generated at a temperature of 20°C. Immediately after the start of exposure, the animals showed attempts to escape, after 1 hour slight irritation of mucous membranes was detected. No clinical signs and findings from the first post observation day onward were found. No mortality occurred during the 7 days of post exposure observation period. No effects were detected at necropsy.

Conclusion: No mortality in male and female rats exposed to saturated vapour at 20°C for 8 h.