Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-629-0 | CAS number: 108-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Orally administered cyclohexylamine is rapidly and almost completely absorbed in both man and animals with peak blood or plasma level occurred between 1 and 2 hours and the half-life ranged from 3 to 5 hours.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Orally administered cyclohexylamine is rapidly and almost completely absorbed in both man and animals (dog, rat, guinea pig, rabbit). After administration of oral doses of 2.5, 5 and 10 mg/kg bw to volunteers, peak blood or plasma level occurred between 1 and 2 hours and the half-life ranged from 3 to 5 hours. In rats and dogs, the peak cyclohexylamine levels in blood or plasma were achieved within the first hour, and the half-lifes were about 1 to 2 hours and 3 hours, respectively (Bopp et al., 1986, Eichelbaum et al., 1974, Renwick and Williams 1972).
In rats the highest concentrations were observed in lungs, spleen, liver, adrenal glands, heart, gastrointestinal tract and kidneys. Only 8% of the cyclohexylamine was bound to plasma protein, whereas binding to human serum albumin was determined at 33%. The apparent distribution volume in humans of 2.1 to 2.9 l/kg agreed well with the values in rats, 2.7 l/kg (Bopp et al., 1986, Eichelbaum et al., 1974).
Cyclohexylamine diffuses across the placental barrier and thus might reach the fetus, as studies in pregnant rhesus monkeys have demonstrated (Bopp et al., 1986, Pitkin et al. 1969).
In humans and in experimental animals approximately 90% or more of the administered dose is eliminated in the urine. In humans, the renal clearance of cyclohexylamine exceeded that of creatinine, as indicated by both by elimination via tubular secretion as well as glomerular filtration. Since the renal clearance decreased when the dose is increased (from 2.5 to 10 mg/kg bw) a low-level of saturability is assumed in the secretion process. (Bopp et al., 1986, Eichelbaum et al., 1974).
Cyclohexylamine is absorbed and eliminated more rapidly by mice than by rats. In rats, plasma clearance in the steady state emounted to approximately half by comparison with that of mice. Contrary to the data found in mice, the concentration of cyclohexylamine in the testes of rats did not correlate with the dose in a linear fashion. The kinetics is therefore devisive in producing the difference in the occurance of testicular effects in rats versus mice (Roberts and Renwick 1989).
Following oral application of 25-50 mg/per person or 50-500 mg/kg in animals 1-2% of the administered dose was metabolized in humans, compared to approx. 10% in female guinea pigs and approx. 30% in rabbits. The only metabolite found was transcyclohexane-1,2-diol. In the rat ring hydroxylation occurred, resulting in isomers of 3- or 4-aminocyclohexanol. In guinea pigs and rabbits deamination (via CYP 450) and ring hydroxylation was reported. Both cyclohexanone and cyclohexanol were identified in dogs (Bopp et al., 1986, Eichelbaum et al., 1974, Kurebayashi et al., 1990, Roberts and Renwick 1989).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)