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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; no detailed information on testing atmosphere and/or

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
Method: rats were exposed to an atmosphere which was satified with vapour at 20°C for 10 min and for 30 min
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG

Test animals

Species:
rat

Administration / exposure

Details on inhalation exposure:
rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min and for 30 min
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 10 - <= 30 min
Concentrations:
a satisfied vapour atmosphere
No. of animals per sex per dose:
no data
Control animals:
no
Details on study design:
rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min (12 rats) and for 30 min (6 rats). To reach a satisfied atmosphere air was piped through a of 5 cm layer of testsubstance at 20 °C
Statistics:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: satisfied vapour atmosphere
Based on:
other: satisfied vapour atmosphere
Exp. duration:
10 min
Remarks on result:
other: mortality 0/12
Sex:
not specified
Dose descriptor:
other: mortality
Based on:
other: satisfied vapour atmosphere
Exp. duration:
30 min
Remarks on result:
other: mortality: 3/6
Mortality:
exposure time: 10 min: 0/12
exposure time 30 min: 3/6
Clinical signs:
other: all animals tried to escape, marked irritations of the mucous membranes, dyspnea (gasping), bloody crusted eyes and nose
Body weight:
no data
Gross pathology:
bloody crusted snouts
Other findings:
no further data

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Executive summary:

Exposusre of 12 rats for 10 min against a vapour saturated test atmosphere caused no death; exposure for 30 min to 6 rats caused the death of 3/6 rats. Clinical signs were displayed of all animals and included marked irritations of the mucous membranes, dyspnea and gasping (BASF 1970)