Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-629-0 | CAS number: 108-91-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation; no detailed information on testing atmosphere and/or
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- Method: rats were exposed to an atmosphere which was satified with vapour at 20°C for 10 min and for 30 min
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Details on inhalation exposure:
- rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min and for 30 min
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 10 - <= 30 min
- Concentrations:
- a satisfied vapour atmosphere
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- rats were exposed to an atmosphere which was satisfied with vapour at 20°C for 10 min (12 rats) and for 30 min (6 rats). To reach a satisfied atmosphere air was piped through a of 5 cm layer of testsubstance at 20 °C
- Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: satisfied vapour atmosphere
- Based on:
- other: satisfied vapour atmosphere
- Exp. duration:
- 10 min
- Remarks on result:
- other: mortality 0/12
- Sex:
- not specified
- Dose descriptor:
- other: mortality
- Based on:
- other: satisfied vapour atmosphere
- Exp. duration:
- 30 min
- Remarks on result:
- other: mortality: 3/6
- Mortality:
- exposure time: 10 min: 0/12
exposure time 30 min: 3/6 - Clinical signs:
- other: all animals tried to escape, marked irritations of the mucous membranes, dyspnea (gasping), bloody crusted eyes and nose
- Body weight:
- no data
- Gross pathology:
- bloody crusted snouts
- Other findings:
- no further data
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Executive summary:
Exposusre of 12 rats for 10 min against a vapour saturated test atmosphere caused no death; exposure for 30 min to 6 rats caused the death of 3/6 rats. Clinical signs were displayed of all animals and included marked irritations of the mucous membranes, dyspnea and gasping (BASF 1970)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
