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Diss Factsheets
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EC number: 203-629-0 | CAS number: 108-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: tables and abstract only
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Cyclohexylamine, a chomosome aberration inducing substance: no teratogenicity in mice
- Author:
- Takano K, Suzuki M
- Year:
- 1 971
- Bibliographic source:
- Senen IjoCongenital anomalies 11, 51-57
- Reference Type:
- review article or handbook
- Title:
- No 283. Cyclohexylamine in
- Author:
- Shepard ThH
- Year:
- 1 986
- Bibliographic source:
- Catalog of teratogenic agents, The John Hopkins University Press, Baltimore and London, pp88-89
Materials and methods
- Principles of method if other than guideline:
- Application of different doses to pregnant female mice from day 6 to day 11 of gestation; day 18: removal of fetuses
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Details on test animals or test system and environmental conditions:
- Room temperature: 21-24 °C
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- Application of different doses to pregnant female mice by gavage from day 6 to day 11 of gestation; day 18: removal of fetuses
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- no data: pregnant mice were used
- Duration of treatment / exposure:
- day 6 to day 11 of gestation
- Frequency of treatment:
- once daily
- Duration of test:
- until day 18 of gestation
- No. of animals per sex per dose:
- i00 mg/kg bw: 17 mothers
50 mg(kg bw: 10 mothers
20 mg7kg bw11 mothers
control: 7 mothers - Control animals:
- yes
- Details on study design:
- Application of different doses to pregnant female mice from day 6 to day 11 of gestation; day 18: removal of fetuses
Examinations
- Maternal examinations:
- mortality
- Ovaries and uterine content:
- all implantation sites
- Fetal examinations:
- body weights external malformations and skeletal abnormalities
- Statistics:
- yes, but method not given
- Indices:
- no
- Historical control data:
- no
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
at 100 mg/kg bw/day mild lethality (no further data)
Effect levels (maternal animals)
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 50 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- dose level:
- Effect level:
- >= 20 - <= 100 mg/kg bw/day
- Based on:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: no other teratogenic effects than observed in controls were reported
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
at body weight of living fetuses was significantly decreased, but no tetatogenic effects were reported
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 50 mg/kg bw/day
- Basis for effect level:
- other: embryotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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