2-propylvaleric acid

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1994

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure according to National Standards without detailed documentation.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: AFNOR T90301

Deviations:

no

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Valproic Acid

IUPAC Name:

Valproic Acid

Constituent 2

Reference substance name:

2-propylvaleric acid

EC Number:

202-777-3

EC Name:

2-propylvaleric acid

Cas Number:

99-66-1

Molecular formula:

C8H16O2

IUPAC Name:

2-propylpentanoic acid

Details on test material:

- Name of test material (as cited in study report): Acide valproique pur (pure valproic acid)
- Lot/batch No.: 4MXS017

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

Name: Daphnia magna Straus, 1820 (Cladocera crustacea), less than 24h-old.
Source: Laboratoire INERIS

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Remarks on exposure duration:

in darkness

Test conditions

Reference substance (positive control):

yes

Remarks:

Potassium dichromate

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

122.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 72.7-207.0

Results with reference substance (positive control):

EC(I)50-24h for Potassium Dichromate
from 1994-07-18 to 1994-07-22 = 1.06mg/L,
from 1994-07-25 to 1994-07-29 = 0.96mg/L,
from 1994-08-01 to 1994-08-05 = 1.34mg/L,
from 1994-08-08 to 1994-08-12 = 1.14mg/L

Any other information on results incl. tables

Valproïc acid:

Concentrations (mg/L)	Number of immobilized daphnia after 48 h					% immobilisation (total: 20)	pH	O2 (mg/L)
	A	B	C	D	Total
0	0	0	0	0	0	0
65	2	2	0	1	5	25
91	2	1	1	0	4	20
128	1	1	1	2	5	25
179	4	4	5	4	17	85
250	5	5	5	5	20	100	5.71	7.2

 

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

With the 48h-EC 50 for Daphnia magna > 100 mg/l the substance is not considered harmful to aquatic invertebrates