Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-777-3 | CAS number: 99-66-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 8.87 mg/L
Additional information
Read across on Sodium Valproate
Method: OECD Test Guideline 211 Data relate to another salt.
Species: Daphnia magna
Exposure duration: 21 d
Reproduction per Survived Parent (Cumulative Offspring per Survived Parent):
21-day NOEC : ≥ 8.87 mg test item/L (time weighted average concentration); ≥ 10 mg test item/L (nominal concentrations)
21-day EC50 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)
21-day EC10 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)
Mortality:
21-day NOEC : ≥ 8.87 mg test item/L (time weighted average concentration); ≥ 10 mg test item/L (nominal concentrations)
21-day EC50 : > 8.87 mg test item/L (time weighted average concentration); > 10 mg test item/L (nominal concentrations)
Signs of Intoxication:
Apart from the reported mortality, dead offspring were observed during the test. According to the Guideline, these dead offspring are not considered in the evaluation of the results
10 mg/L was the highest tested dose.
Based on the read across on sodium valproate, valproic acid is expected to have a 21-day NOEC ≥ 8.87 mg test item/L and a 21-day EC50 : > 8.87 mg test item/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
