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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable documented study report, which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973
Title:
Acute toxicologic evaluation of Santocure vulcanization accelerator
Author:
Randall, D.J. and Bannister, R.M.,
Year:
1990
Bibliographic source:
Acute Toxic. Data 1 (2), 105-106

Materials and methods

Principles of method if other than guideline:
The acute oral toxicity of CBS was evaluated in an acceptable documented study with Sprague-Dawley Albino rats. A 25 % solution-suspension of CBS in corn oil was administered by gavage to 4 groups of 5 Sprague-Dawley albino rats at doses of 3980, 5010, 6310 and 7940 mg/kg bw. A 7-day observation period followed administration.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 in dataset of Monsanto

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
3980, 5010, 6310, 7940 mg/kg bw
No. of animals per sex per dose:
5 per dose group (mixed males and females; 2-3 males per group, 2-3 females per group).
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
5 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Signs of Intoxication: Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death Gross autopsy: lung and liver hyperemia and acute gastrointestinal inflammation.
Mortality:
3980 mg/kg bw: 0/5 animals died; 5010 mg/kg bw: 1/5 animals died; 6310 mg/kg bw: 4/5 animals died; 7940 mg/kg bw: 4/5 animals died.
Clinical signs:
Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death.
Body weight:
No data.
Gross pathology:
Decendents: lung and liver hyperemia and acute gastrointestinal inflammatuion.
Survivors: Vicera of surviving animals appeared normal at sacrifice.

Any other information on results incl. tables

Signs of Intoxication: Reduced appetite and activity (two to four days in survivors), increased weakness, ocular discharge, slight tremors, collapse, and death.

Gross autopsy:

Decendents: lung and liver hyperemia and acute gastrointestinal inflammatuion.

Survivors: Vicera of surviving animals appeared normal at sacrifice.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information
Conclusions:
LD50 = 5300 mg/kg bw.
Executive summary:

The acute oral toxicity of CBS was evaluated in an acceptable documented study with Sprague-Dawley Albino rats. A 25 % solution-suspension of CBS in corn oil was administered by gavage to t groups of 5 (mixed males and females) Sprague-Dawley albino rats at doses of 3980, 5010, 6310 and 7940 mg/kg bw. A 7-day observation period followed administration. The acute oral LD50 for CBS for male and female rats was calculated to be 5300 mg/kg bw (Monsanto Co. 1973).