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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited documented study report, with restrictions (e.g. no local effects recorded), sufficient for risk assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973
Reference Type:
publication
Title:
Acute toxicologic evaluation of Santocure vulcanization accelerator
Author:
Randall, D.J. and Bannister, R.M.,
Year:
1990
Bibliographic source:
Acute Toxic. Data 1 (2), 105-106

Materials and methods

Principles of method if other than guideline:
A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14-d observation period followed application.
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 in dataset of Monsanto

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
corn oil
Duration of exposure:
24 h
Doses:
5010, 7940 mg/kg bw.
No. of animals per sex per dose:
1-2/dose.
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Clinical signs: reduced appetite and activity three to five days.
Mortality:
No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).
Clinical signs:
Reduced appetite and activity three to five days.
Gross pathology:
Viscera of animals appeared normal at sacrifice.

Any other information on results incl. tables

No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).

Clinical signs: reduced appetite and activity three to five days.

Viscera of animals appeared normal at sacrifice.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 > 7940 mg/kg bw.
Executive summary:

The acute dermal toxicity of the test substance CBS was evaluated with New Zealand Albino rabbits in a limited documented study. A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14 -d observation period followed application. No mortality was observed up to 7940 mg/kg bw. Clinical signs noted included reduced appetite and activity for 3 to 5 days. Viscera of animals appeared normal at sacrifice (Monsanto 1973).