N-cyclohexylbenzothiazole-2-sulfenamide

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited documented study report, with restrictions (e.g. no local effects recorded), sufficient for risk assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Reference 2

Reference Type:

publication

Title:

Acute toxicologic evaluation of Santocure vulcanization accelerator

Author:

Randall, D.J. and Bannister, R.M.,

Year:

1990

Bibliographic source:

Acute Toxic. Data 1 (2), 105-106

Materials and methods

Principles of method if other than guideline:

A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14-d observation period followed application.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

N-cyclohexylbenzothiazole-2-sulfenamide

EC Number:

202-411-2

EC Name:

N-cyclohexylbenzothiazole-2-sulfenamide

Cas Number:

95-33-0

Molecular formula:

C13H16N2S2

IUPAC Name:

N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine

Details on test material:

IUCLID4 Test substance: other TS: as prescribed by chapter 1 in dataset of Monsanto

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

corn oil

Duration of exposure:

24 h

Doses:

5010, 7940 mg/kg bw.

No. of animals per sex per dose:

1-2/dose.

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 7 940 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Clinical signs: reduced appetite and activity three to five days.

Mortality:

No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).

Clinical signs:

other: Reduced appetite and activity three to five days.

Gross pathology:

Viscera of animals appeared normal at sacrifice.

Any other information on results incl. tables

No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).

Clinical signs: reduced appetite and activity three to five days.

Viscera of animals appeared normal at sacrifice.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 > 7940 mg/kg bw.

Executive summary:

The acute dermal toxicity of the test substance CBS was evaluated with New Zealand Albino rabbits in a limited documented study. A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14 -d observation period followed application. No mortality was observed up to 7940 mg/kg bw. Clinical signs noted included reduced appetite and activity for 3 to 5 days. Viscera of animals appeared normal at sacrifice (Monsanto 1973).