Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 231-634-8 | CAS number: 7664-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Proprietary skin and eye irritation studies are available with the diluted substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Justification for type of information:
- Hydrogen fluoride is classified according to the CLP Regulation (EC) 1272/2008 as Skin Corrosion Category 1A, this classification is consistent with data reviewed. A waiver is therefore proposed for the skin irritation/corrosion endpoint in accordance with Annex VII, Standard information requirement 8.1, column 2 , of the REACH regulation. Additional testing for skin irritation/corrosion is therefore not required and is considered unjustified both scientifically and on animal welfare grounds.
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
- Justification for type of information:
- Hydrogen fluoride is classified according to the CLP Regulation (EC) 1272/2008 as Skin Corrosion Category 1A, This classification is consistent with data reviewed. A waiver is therefore proposed for the Serious eye damage/eye irritation endpoint in accordance with Annex VII, Standard information requirement 8.2, column 2, of the REACH regulation. Additional testing for serious eye damage/eye irritation is therefore not required and is considered unjustified both scientifically and on animal welfare grounds.
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
HF is classified as Corrosive (R35), therefore no studies are required. However some data are available and are reported. In a standard OECD 404 study performed with 5% hydrofluoric acid, Martins (1990) reports corrosive effects. Thyssen (1981) notes no local dermal effects in a study performed with 0.13% and 1.06% hydrofluoric acid. Wang et al report that 20% of HF was enough to cause skin damage in the rat and might bring about fatal hypocalcemia after a prolonged contact. High concentrations of HF (40%) caused deep tissue necrosis within a short time and resulted in fatal hypocalcemia within 24 hours even in the case of a small area injury. Klauder et al (1955) report no dermal reactions in rabbits resulting from application of 1%, 2% and 4% HF. Transitory blanching occurred at 6%, 8% and 10%. After application of 12%, 15% 18% and 22% crust formation appeared in about 24 hours at site of blanching and disappeared in about one week. Application of 25% and 30% caused blanching followed by redness, later crust formation. These effects were observed from 35% and 40% and in addition, blistering and superficial ulceration. These reactions were more pronounced from 50% concentration and were followed by deep ulceration. The EU RAR for HF also notes that, in humans, dermal contact with HF can cause second and third degree burns which are associated with severe pain and which heal very slowly.
Eye irritation
HF is classified as Corrosive (R35), therefore no studies are required. However some data are available and are reported. Thyssen (1981) notes no ocular effects with 0.13% hydrofluoric acid and moderate irritation with 1.06% hydrofluoric acid.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Hydrogen fluoride is classified according to the CLP Regulation (EC) 1272/2008 in Skin Corrosion Class 1A. This classification is consistent with the data reviewed and no change is proposed.
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