Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry
Author:
Anderson, Stacey E. et al.
Year:
2007
Bibliographic source:
Toxicological Sciences 97(2), 355-363

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
TOPKAT 6.2 (Accelrys, Inc, San Diego, CA) and Derek for Windows version 9.0.0 (Lhasa Limited, Leeds, UK), together with the NIOSH
logistic regression model (Fedorowicz et al., 2005) were used to estimate the sensitization potential of 4 chemicals. Furthermore, local lymph node and phenotypic analysis were performed. Glyoxal and diacetyl are known sensitizers with published EC3 values. Along with methylglyoxal and
glycolaldehyde, they were observed as reaction products from simulated indoor environment gas-phase chemistry (Forester et al., 2006; Ham et al., 2006; Wells, 2005)

Test material

Constituent 1
Chemical structure
Reference substance name:
Glyoxal
EC Number:
203-474-9
EC Name:
Glyoxal
Cas Number:
107-22-2
Molecular formula:
C2H2O2
IUPAC Name:
oxalaldehyde

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification