Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 915-277-1 | CAS number: 32052-51-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolysis of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate was studied according to OECD Guideline No. 111 (2004) and Council Regulation (EC) No. 440/2008, Method C.7 with a test item concentration of 100 µg/L in buffer solutions of pH 4, 7 and 9 at temperatures of 10, 20 and 30 °C. Rapid hydrolysis following pseudo-first order kinetics with the following half-lives was observed:
pH 4: 8.08 min (10 °C), 3.81 min (20 °C), 2.51 min (30 °C)
pH 7: 12.1 min (10 °C), 4.88 min (20 °C), 2.15 min (30 °C)
pH 9: 5.78 min (10 °C), 1.93 min (20 °C), 0.74 min (30 °C)
Apparently, the base catalysed hydrolysis is the fastest hydrolysis process.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4.88 min
- at the temperature of:
- 20 °C
Additional information
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