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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Environmental fate & pathways


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Administrative data

Link to relevant study record(s)

Description of key information

The hydrolysis of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate was studied according to OECD Guideline No. 111 (2004) and Council Regulation (EC) No. 440/2008, Method C.7 with a test item concentration of 100 µg/L in buffer solutions of pH 4, 7 and 9 at temperatures of 10, 20 and 30 °C. Rapid hydrolysis following pseudo-first order kinetics with the following half-lives was observed:
pH 4: 8.08 min (10 °C), 3.81 min (20 °C), 2.51 min (30 °C)
pH 7: 12.1 min (10 °C), 4.88 min (20 °C), 2.15 min (30 °C)
pH 9: 5.78 min (10 °C), 1.93 min (20 °C), 0.74 min (30 °C)
Apparently, the base catalysed hydrolysis is the fastest hydrolysis process.

Key value for chemical safety assessment

Half-life for hydrolysis:
4.88 min
at the temperature of:
20 °C

Additional information