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Environmental fate & pathways

Hydrolysis

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Description of key information

The hydrolysis of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate was studied according to OECD Guideline No. 111 (2004) and Council Regulation (EC) No. 440/2008, Method C.7 with a test item concentration of 100 µg/L in buffer solutions of pH 4, 7 and 9 at temperatures of 10, 20 and 30 °C. Rapid hydrolysis following pseudo-first order kinetics with the following half-lives was observed:
pH 4: 8.08 min (10 °C), 3.81 min (20 °C), 2.51 min (30 °C)
pH 7: 12.1 min (10 °C), 4.88 min (20 °C), 2.15 min (30 °C)
pH 9: 5.78 min (10 °C), 1.93 min (20 °C), 0.74 min (30 °C)
Apparently the base catalyzed hydrolysis is the fastest hydrolysis process.

Key value for chemical safety assessment

Half-life for hydrolysis:
4.88 min
at the temperature of:
20 °C

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