Registration Dossier
Registration Dossier
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EC number: 915-277-1 | CAS number: 32052-51-0
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.064 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.64 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.006 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.32 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 144.678 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 14.468 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 27.087 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
The most sensitive organism in acute toxicity tests with 2,2,4(or 2,4,4)-Trimethylhexane-1,6 -diisocyanate is Daphnia magna with an EC50 of 64.0 mg/L. The substance is not readily biodegradable and a log Kow is not available as the substance hydrolyses rapidly (t 1/2 <5 min). The degradation product is 2,2,4 (or 2,4,4)-trimethylhexane-1,6-diamine with an experimentally derived log Kow of -0.3 at 25 °C and pH 7.5 and no biodegradation potential. Both substances are classified as aquatic chronic 3 according to CLP regulation 1272/2008.
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