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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

For 2,2,4 (or 2,4,4)-trimethylhexane-1,6 -diisocyanate acute studies with organisms from 3 different trophic levels are available. For all tests a stock solution was prepared with a concentration of 1 g/L. The solution was stirred for 18 hours and filtered afterwards.

The acute toxicity of the test substance to Brachydanio rerio was evaluated in a semi static fish test over a period of 96 hours (Hüls AG 1994) according to EU method C.1. Five concentrations ranging from 100 to 1000 mg/L (nominal) were tested. The test substance was found to be stable under the test conditions (DOC determination). The LC50 (96 hours) was determined to be >328 mg/L.

A static test over a period of 48 hours was performed with Daphnia magna according to EU method C.2. Seven concentrations ranging from 39.5 to 316.0 mg/L (nominal) were tested and the EC50 (48 h) was determined as 64 mg/L (95% CL: 48.7 - 84.1%).

The toxicity to algae (Scenedesmus subspicatus) was evaluated in a static test over a period of 72 hours (Hüls AG 1993) according to EU method C.3. Five concentrations ranging from 28.0 to 253.0 mg/L (nominal) were tested. The ErC50 (72 h) was determined as >256 mg/L. The NOEC was determined as 170 mg/L. The lowest valid EC50 value is 64 mg/L.