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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Asthma durch Isocyanate
Author:
Baur X
Year:
1986
Bibliographic source:
Allergologie 9, 487-496

Materials and methods

Endpoint addressed:
respiratory irritation

Test material

Constituent 1
Reference substance name:
Trimethylhexa-1,6-diyl diisocyanate
EC Number:
249-151-6
EC Name:
Trimethylhexa-1,6-diyl diisocyanate
Details on test material:
Isocyanates in general (analogy)

Method

Type of population:
occupational
Examinations:
In a 4-year epidemological investigation finished in 1983, 247 out of 621  employees included in the study (working mainly in the chemical and  
automobile-producing industry) were found to suffer from  isocyanate-related diseases (type of compound not specified). In 290  cases, the 
respiratory system was affected, in some cases, evidence for  hypersensitivity pneumonitis was obtained.

Results and discussion

Applicant's summary and conclusion