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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Adsorption / desorption

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Administrative data

Link to relevant study record(s)

Description of key information

Testing for adsorption / desorption is not possible because the substance reacts with water, see IUCLID Chapter 5.1.2.

Key value for chemical safety assessment

Koc at 20 °C:
22 570

Additional information

With a calculated Koc of 22570 l/kg, the sorption potential of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate to soil or sediment organic matter is expected to be very high (Blume scale). However, environmental distribution considerations for 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate are of little relevance because the reaction with water is expected to eliminate the substance from the environment rapidly.


The adsorption coefficient of the unpolmerised hydrolysis product 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine corrected for dissociation was calculated with a QSAR published by Franco and Trapp (2008). The result was Koc = 25, log Koc = 1.40 (pH 7), corresponding to a very low potential for geoaccumulation (Blume scale).