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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

According to a Mackay Level I model calculation, the main target compartment for 2,2,4(2,4,4)-trimethylhexane-1,6-diamine will be the hydrosphere (99.97 %), followed the atmosphere 0.02 %). The calculated Henry’s law constant of 0.00063 Pa m3/mol indicates very low volatility of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine from surface waters. The adsorption coefficient of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine corrected for dissociation was calculated with a QSAR published by Franco and Trapp (2008). The result was Koc = 25, log Koc = 1.40 (pH 7), corresponding to a very low potential for geoaccumulation (Blume scale).


The QSAR calculated rate constant for the OH sensitized photodegradation of 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine is approximately 6.96E-11 cm3/(molecule * s). At 500,000 OH radicals / cm3 (approximate 24-hour mean in central Europe), this corresponds to a half-life of 5.5 hours.Screening tests on biodegradation in water showed that the substance is neither readily nor inherently degradable. In spite of these findings biodegradation and OH sensitized photodegradation are expected to be the predominant ways of removal from the environment while hydrolytical degradation in surface waters is expected to be of minor importance. The partition coefficient 1-octanol/water is log Kow = -0.3 at 25 °C, indicating negligible potential for bioaccumulation.