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Administrative data

Description of key information

2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine is of moderate oral acute toxicity with an oral LD50(rat) of 910 mg/kg bw ( Klimmer, 1965). According 
to REACH Annex VIII, 8.5. column 2, acute dermal and inhalative toxicity studies do not need to be conducted if the substance is classified
as corrosive to the skin.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
910 mg/kg bw

Additional information

2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine was applied once to 5 dose-groups of rats (5 male Wistar rats per dose-group) in doses of 217; 434; 650; 867; 1080 mg/kg bw as 50 % v/v solution in water. The animals were observed for mortality and any sub-lethal effects for 14 days after dosing.

Animals died within 12- 18 hours after oral application of the test item in lateral position. Clinical signs were irritation of the intestinal mucosa with some rats showed slight increase in kidney weight and protein in the urine. In all dose groups an increase in activity, rough fure, decrease of food consumption and lethargie was observed beginning 1 hour after dosing.

According to this study the LD50value (oral) was determined to be 910 mg/kg bw in rats. Therefore under the conditions of this study 2,2,4(or 2,4,4)-trimethylhexane-1,6-diamine is harmful if swallowed.

Justification for classification or non-classification

According to the criteria of EC Directive 67/548/EEC and EC Regulation 1272/2008

2,2,4(or 2,4,4)-trimethylhexane-1,6-diamin is classified as harmful if swallowed.