Registration Dossier
Registration Dossier
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EC number: 203-463-9 | CAS number: 107-11-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Old study, not to GLP, but sufficiently similar to current guidelines
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicity of Allylamines
- Author:
- Hine, CH et al
- Year:
- 1 960
- Bibliographic source:
- Archives of Environmental Health, Volume 1, Pages 343-352
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Number of animals not stated
- GLP compliance:
- no
- Remarks:
- Old study
Test material
- Reference substance name:
- Allylamine
- EC Number:
- 203-463-9
- EC Name:
- Allylamine
- Cas Number:
- 107-11-9
- Molecular formula:
- C3H7N
- IUPAC Name:
- prop-2-en-1-amine
- Test material form:
- other: liquid
- Details on test material:
- Molecular weight: 57.09
Boiling point: 52.9 deg C
Melting point: -88.2 deg C
Flash point, tag open cup: -20 deg F
Specific Gravity, 20/4 C: 0.7627
Solubility in water, 20 deg C, %W: complete
pH of 0.1M aqueous solution: 11.2
ppm in 1 mg/mL: 429
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No further details stated
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.05 mL applied to centre of cornea
- Duration of treatment / exposure:
- No details available
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- Not stated
- Details on study design:
- Eyes examined in strong diffuse light, both unstained and stained with fluorescein solution. To be evaluated using Draize scores
Results and discussion
In vivo
Results
- Irritation parameter:
- other: too irritating to score
- Reversibility:
- not specified
- Remarks on result:
- other: extremely irritant
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: authors opinion
- Conclusions:
- Allylamine is extremely irritant to the eye
- Executive summary:
Allylamine is extremely irritant to the eye, and the reaction did not permit differential readings
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