Registration Dossier
Registration Dossier
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EC number: 206-056-4 | CAS number: 298-07-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- 100 µl bis(2-ethylhexyl) hydrogen phosphate was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of bis(2-ethylhexyl) hydrogen phosphate up to 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) hydrogen phosphate
- EC Number:
- 206-056-4
- EC Name:
- Bis(2-ethylhexyl) hydrogen phosphate
- Cas Number:
- 298-07-7
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- bis(2-ethylhexyl) hydrogen phosphate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable - score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
Any other information on results incl. tables
Bis(2-ethylhexyl) hydrogen phosphate causes corrosion to the cornea.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
100 µl bis(2-ethylhexyl) hydrogen phosphate was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of bis(2-ethylhexyl) hydrogen phosphate up to 7 days.
Bis(2-ethylhexyl) hydrogen phosphate was highly irritating to the eye and corrsive to the cornea. Effects on the cornea, conjunctiva and chemosis were persistent up to the end of the observation period (7 days).
Therefore a classification as R41 is justified.
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