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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Study performed prior to current scientific methods. Insufficient to provide usable results.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1928

Materials and methods

Principles of method if other than guideline:
Rabbits were exposed to the test substance via i.p. injection.
GLP compliance:
no

Test material

Constituent 1
Details on test material:
- Purity: Not reported

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
Protocol #1 - 114 hours (approx. 4.75 days) after first injection
Protocol #2 - Approx. 4 weeks after first injection
Frequency of treatment:
Protocol #1 initial injection, 48 hours later, 114 hours after initial injection
Protocol #2 initial injection, 48 hours later, 114 hours, 326 hours after initial injection, and then two weeks later.
Doses / concentrations
Remarks:
Doses / Concentrations:
Protocol #1 - 10 cc volume of a 1% in water
Protocol #2 - 10 cc volume of a 1% in 2% calcium chloride and water
No. of animals per sex per dose:
2 rabbits
Control animals:
no

Results and discussion

Effect levels

Sex:
not specified
Basis for effect level:
other: see 'Remark'
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

Rabbits were exposed to the test substance via i.p. injection. The test substance on living rabbits manifests its action first peripherally (loss of locomotion), second by early acceleration of respiration, third by salivation, sonorous and laboured breathing, oedema of the tongue, nose, face, neck and salivary glands, or if a sufficient amount is given clonic seizures terminate the life of the animal before the oedema stage is reached.

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