Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
publication
Title:
Dermal Absorption Potential of Industrial Chemicals: Criteria for Skin Notation
Author:
Fiserova-Bergerova V, Pierce TJ, Droz PO
Year:
1990
Bibliographic source:
American Journal of Industrial Medicine 17: 617-635

Materials and methods

Principles of method if other than guideline:
The dermal penetration rate (flux) was predicted from physical properties

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Test material form:
solid
Details on test material:
Not applicable for in silico study.

Results and discussion

Any other information on results incl. tables

A calculated dermal flux of 1.26 mg/cm2 per hour was reported in the publication for cyclohexanol. A dermal uptake of 2520 mg/hour can then be estimated (assumptions: 2000 cm2 of skin surface area exposed to cyclohexanol in solution).

Applicant's summary and conclusion

Conclusions:
The model predicts skin penetration of cyclohexanol based on the physical chemical properties of the substance.