Registration Dossier
Registration Dossier
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EC number: 203-630-6 | CAS number: 108-93-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- Methodological deficiencies (inappropriate route of exposure)
Data source
Reference
- Reference Type:
- publication
- Title:
- The pharmacology of certain terpene alcohols and oxides
- Author:
- Northover BJ and Verghese J
- Year:
- 1 962
- Bibliographic source:
- Sci. Ind. Res., Section C: Biol. Sci. 21, 342-345 (1962)
Materials and methods
- Principles of method if other than guideline:
- Groups each of 10 animals received intramuscular injections of the test substance. The number of animals which died in the course of the next 48h period was noted.
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexanol
- EC Number:
- 203-630-6
- EC Name:
- Cyclohexanol
- Cas Number:
- 108-93-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- cyclohexanol
- Test material form:
- not specified
- Details on test material:
- Supplier: not specified.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- 10
- Details on study design:
- Mortality within 48h was used to determine LD50
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: LD 50 within 48h post application
- Mortality:
- Death occured usually within the first 12h from the time when the drug was administered.
Any other information on results incl. tables
A graph was plotted of the dose administered against number of animals which died and from this graph the dose which would kill 50% of the animals in a group was calculated
Applicant's summary and conclusion
- Conclusions:
- The 48-hour LD50 value in this study on the acute toxicity of cyclohexanol to the mouse after intramuscular injection was 1000 mg/kg bw.
- Executive summary:
The acute toxicity of cyclohexanol to the mouse following intramuscular injection was studied under non-GLP, non-guideline conditions. The 48-hour LD50 value in this study was found to be 1000 mg/kg bw.
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