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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system
Remarks:
Methodological deficiencies (inappropriate route of exposure)

Data source

Reference
Reference Type:
publication
Title:
The pharmacology of certain terpene alcohols and oxides
Author:
Northover BJ and Verghese J
Year:
1962
Bibliographic source:
Sci. Ind. Res., Section C: Biol. Sci. 21, 342-345 (1962)

Materials and methods

Principles of method if other than guideline:
Groups each of 10 animals received intramuscular injections of the test substance. The number of animals which died in the course of the next 48h period was noted.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Supplier: not specified.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intramuscular
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
10
Details on study design:
Mortality within 48h was used to determine LD50

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Remarks on result:
other: LD 50 within 48h post application
Mortality:
Death occured usually within the first 12h from the time when the drug was administered.

Any other information on results incl. tables

A graph was plotted of the dose administered against number of animals which died and from this graph the dose which would kill 50% of the animals in a group was calculated

Applicant's summary and conclusion

Conclusions:
The 48-hour LD50 value in this study on the acute toxicity of cyclohexanol to the mouse after intramuscular injection was 1000 mg/kg bw.
Executive summary:

The acute toxicity of cyclohexanol to the mouse following intramuscular injection was studied under non-GLP, non-guideline conditions. The 48-hour LD50 value in this study was found to be 1000 mg/kg bw.