Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system
Remarks:
Methodological deficiencies (inappropriate route of exposure)

Data source

Reference
Reference Type:
publication
Title:
The pharmacology of certain terpene alcohols and oxides
Author:
Northover BJ and Verghese J
Year:
1962
Bibliographic source:
Sci. Ind. Res., Section C: Biol. Sci. 21, 342-345 (1962)

Materials and methods

Principles of method if other than guideline:
Groups each of 10 animals received intramuscular injections of the test substance. The number of animals which died in the course of the next 48h period was noted.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Test material form:
not specified
Details on test material:
Supplier: not specified.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intramuscular
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
10
Details on study design:
Mortality within 48h was used to determine LD50

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Remarks on result:
other: LD 50 within 48h post application
Mortality:
Death occured usually within the first 12h from the time when the drug was administered.

Any other information on results incl. tables

A graph was plotted of the dose administered against number of animals which died and from this graph the dose which would kill 50% of the animals in a group was calculated

Applicant's summary and conclusion

Conclusions:
The 48-hour LD50 value in this study on the acute toxicity of cyclohexanol to the mouse after intramuscular injection was 1000 mg/kg bw.
Executive summary:

The acute toxicity of cyclohexanol to the mouse following intramuscular injection was studied under non-GLP, non-guideline conditions. The 48-hour LD50 value in this study was found to be 1000 mg/kg bw.