Registration Dossier
Registration Dossier
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EC number: 203-630-6 | CAS number: 108-93-0
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Inappropriate route of exposure
Data source
Reference
- Reference Type:
- publication
- Title:
- Ueber die pharmakologishen Wirkungen der Hydroaromatischen Verbindungen: Cyclohexen, Cyclohexan und Cyclohexanol
- Author:
- Sato K
- Year:
- 1 928
- Bibliographic source:
- Jpn. J. Med. Sci. Part 4: Pharmacol. 3, 1-62
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Version / remarks:
- Study was performed in 1928.
- Principles of method if other than guideline:
- Not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexanol
- EC Number:
- 203-630-6
- EC Name:
- Cyclohexanol
- Cas Number:
- 108-93-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- cyclohexanol
- Test material form:
- not specified
- Details on test material:
- Supplier: not specified.
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Not specified
- Purity: Not specified
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 475 mg/kg bw/day
- Remarks:
- Calculated from 500 microlitre/kg/d by conversion with density (0.95 g/mL)
- Dose / conc.:
- 950 mg/kg bw/day
- Remarks:
- Calculated from 1000 microlitre/kg/d by conversion with density (0.95 g/mL)
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- - Post-exposure period: no
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- No significant changes in the blood counts.
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- No macroscopic change of the liver
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Increased erythrocytes and leucocytes in bone marrow, no significant change of the lymph nodes, kidneys, spleen and appendix. Slight atrophy of the liver cells was reported.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Remarks on result:
- not determinable
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
