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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Inappropriate route of exposure

Data source

Reference
Reference Type:
publication
Title:
Ueber die pharmakologishen Wirkungen der Hydroaromatischen Verbindungen: Cyclohexen, Cyclohexan und Cyclohexanol
Author:
Sato K
Year:
1928
Bibliographic source:
Jpn. J. Med. Sci. Part 4: Pharmacol. 3, 1-62

Materials and methods

Test guideline
Qualifier:
no guideline available
Version / remarks:
Study was performed in 1928.
Principles of method if other than guideline:
Not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Test material form:
not specified
Details on test material:
Supplier: not specified.
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Not specified
- Purity: Not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Duration of treatment / exposure:
10 days
Frequency of treatment:
Daily
Doses / concentrationsopen allclose all
Dose / conc.:
475 mg/kg bw/day
Remarks:
Calculated from 500 microlitre/kg/d by conversion with density (0.95 g/mL)
Dose / conc.:
950 mg/kg bw/day
Remarks:
Calculated from 1000 microlitre/kg/d by conversion with density (0.95 g/mL)
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
- Post-exposure period: no

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
no effects observed
Description (incidence and severity):
No significant changes in the blood counts.
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Description (incidence and severity):
No macroscopic change of the liver
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Description (incidence and severity):
Increased erythrocytes and leucocytes in bone marrow, no significant change of the lymph nodes, kidneys, spleen and appendix. Slight atrophy of the liver cells was reported.
Histopathological findings: neoplastic:
not specified
Other effects:
not specified

Effect levels

Remarks on result:
not determinable

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion