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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Inappropriate route of exposure

Data source

Reference
Reference Type:
publication
Title:
Ueber die pharmakologishen Wirkungen der Hydroaromatischen Verbindungen: Cyclohexen, Cyclohexan und Cyclohexanol
Author:
Sato K
Year:
1928
Bibliographic source:
Jpn. J. Med. Sci. Part 4: Pharmacol. 3, 1-62

Materials and methods

Test guideline
Qualifier:
no guideline available
Version / remarks:
Study was performed in 1928.
Principles of method if other than guideline:
Not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexanol
EC Number:
203-630-6
EC Name:
Cyclohexanol
Cas Number:
108-93-0
Molecular formula:
C6H12O
IUPAC Name:
cyclohexanol
Test material form:
not specified
Details on test material:
Supplier: not specified.
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Not specified
- Purity: Not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Duration of treatment / exposure:
10 days
Frequency of treatment:
Daily
Doses / concentrationsopen allclose all
Dose / conc.:
475 mg/kg bw/day
Remarks:
Calculated from 500 microlitre/kg/d by conversion with density (0.95 g/mL)
Dose / conc.:
950 mg/kg bw/day
Remarks:
Calculated from 1000 microlitre/kg/d by conversion with density (0.95 g/mL)
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
- Post-exposure period: no

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
no effects observed
Description (incidence and severity):
No significant changes in the blood counts.
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Description (incidence and severity):
No macroscopic change of the liver
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Description (incidence and severity):
Increased erythrocytes and leucocytes in bone marrow, no significant change of the lymph nodes, kidneys, spleen and appendix. Slight atrophy of the liver cells was reported.
Histopathological findings: neoplastic:
not specified
Other effects:
not specified

Effect levels

Remarks on result:
not determinable

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion