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Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, short documentation. Sex of animals not given. Breath not analysed, purity not specified, reliability of detection method unclear

Data source

Reference
Reference Type:
publication
Title:
The decomposition of muconic and adipic acids in the animal body.
Author:
Mori Y
Year:
1918
Bibliographic source:
J. Biol. Chem. 35, 341-351.

Materials and methods

Objective of study:
excretion
Principles of method if other than guideline:
Rabbits, 2.7-3.5 kg in weight, were dosed with adipic acid by the s.c. route. Three rabbits were dosed by single administration of 2000mg, one animal was dosed twice (days 1 and 5) and one animal was dosed  four times (days 1, 5,  9, 13, 15). Urine was collected and adipic acid  and oxalic acid concentrations were monitored. 
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Adipic acid
EC Number:
204-673-3
EC Name:
Adipic acid
Cas Number:
124-04-9
Molecular formula:
C6H10O4
IUPAC Name:
adipic acid
Details on test material:
IUCLID4 Test substance: purity not specified

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.
Toxicokinetic parameters
Toxicokinetic parameters:
other: In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid concentrations in the urine were observed.

Any other information on results incl. tables

In average 61 % of the adipic acid doses were recovered unchanged in the urine, and increase of the oxalic acid
concentrations in the urine were observed.

Applicant's summary and conclusion