Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, short documentation, purity not specified, only 7 days post observation period, statistics used not specified

Data source

Reference
Title:
No information
Author:
Horn HJ, Holland EG, Hazleton LW (1957). Safety of adipic acid as compared with citric and tartaric acid. Agricult. Food Chem. 5, 759-762.

Materials and methods

Principles of method if other than guideline:
End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "any information on materials and methods including tables".
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: purity not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 3% aqueous solution
Doses:
200, 300, 350 mg/kg bw
No. of animals per sex per dose:
7

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
275 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
Mortality occurred during the first 5 days (200 mg/kg bw =
1/7, 300 mg/kg bw = 4/7, 350 mg/kg bw = 6/7). Animals that
succumbed showed hemorrhagic lungs and irritation of the
intestines. The survivors showed extensive irritation and
adhesions of the visceral organs.

Applicant's summary and conclusion