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EC number: 203-643-7 | CAS number: 109-06-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, non guideline study. Published in peer reviewed literature. Minor restrictions in design and reporting but adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative acute toxicity and primary irritancy of various classes of amines
- Author:
- Myers, R.C., and Ballantyne, B.
- Year:
- 1 997
- Bibliographic source:
- Toxic Substance Mechanisms 16, 151-193
Materials and methods
- Principles of method if other than guideline:
- Male Wistar albino rats were orally exposed to the test substance by gavage followed by a 14 day observation period. Besides mortality, animal weight was recorded. Necropsy was performed on all animals that died and on sacrificed survivors to examine for gross pathology.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
- Details on test material:
- - Name of test material (as cited in study report): a-Picoline (2-methyl-pyridine)
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-4 wk
- Weight at study initiation: 90-120 g
- Fasting period before study: No fasting took place
- Diet: Commercial rodent feed, ad libitum
- Water: Municipal water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: On the day of dosing, and 14 d post dosing.
- Necropsy of survivors performed: yes
- Other examinations performed: Gross pathology - Statistics:
- LD50 values and their 95% confidence limits were calculated by the moving average method of Thompson (1947) and the tables of Weil (1983).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 885 mg/kg bw
- 95% CL:
- 600 - 1 314
- Remarks on result:
- other: Value reported 0.93 (0.63-1.38) mL/kg
- Mortality:
- Animals died within 4 hours after dosing.
- Clinical signs:
- other: - Rapid progression of lethargy, laboured breathing, ataxia, and prostration, all occurring within a few minutes. - Convulsions at day 1.
- Gross pathology:
- - Animals that died: lung haemorrhage, congested kidneys, and hyperaemic stomachs and/or intestines.
- Animals that survived: most survivors showed no gross pathology, a few had lung haemorrhages.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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