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EC number: 203-643-7 | CAS number: 109-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non guideline study. GLP-status unknown. Published in peer reviewed literature. Restrictions in design and reporting but adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Genetic and anti-tubulin effects induced by pyridine derivatives
- Author:
- Zimmermann F.K., Henning J.H., Scheel I., Oehler, M.
- Year:
- 1 986
- Bibliographic source:
- Mutation Research, 163, 23-31
- Reference Type:
- review article or handbook
- Title:
- SCIENTIFIC OPINION Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 013
- Bibliographic source:
- EFSA Journal 2013;11(11):3453
Materials and methods
- Principles of method if other than guideline:
- The test substance was evaluated for its potential to induce mitotic aneuploidy, mitotic recombination and anti-tubulin effects in yeast strain S. cerevisiae D61.M.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methylpyridine
- EC Number:
- 203-643-7
- EC Name:
- 2-methylpyridine
- Cas Number:
- 109-06-8
- Molecular formula:
- C6H7N
- IUPAC Name:
- 2-methylpyridine
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Saccharomyces cerevisiae
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0.50, 0.55, 0.60, 0.65, 0.70, 074 % (Highest dose tested 6988 μg/mL)
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- no
- Details on test system and experimental conditions:
- - The test substance was tested in a liquid yeast-peptone medium. The cell titers at the time of addition were between 1 and 2E7 cells per mL.
- Incubation in the presence of the test substance was carried out at 28°C for 4 h. The cultures were then placed into an ice bath and kept overnight for about 16-17 h. A final growth period of another 4 h at 28°C followed before the cells were plated.
Results and discussion
Test results
- Species / strain:
- Saccharomyces cerevisiae
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Additional information on results:
- Induction of chromosome loss and other genetic changes: weakly active. This effect was only observed at very high doses. The effect is however considered thresholded (EFSA Journal 2013;11(11):3453).
Induction of anti-tubulin effects: not induced - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive At high concentrations
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