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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Study period:
1993
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliable source.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
Version / remarks:
prolonged to 28 days
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-2-(4-chloro-2-methylphenoxy)propionic acid
EC Number:
240-539-0
EC Name:
(R)-2-(4-chloro-2-methylphenoxy)propionic acid
Cas Number:
16484-77-8
Molecular formula:
C10H11ClO3
IUPAC Name:
(2R)-2-(4-chloro-2-methylphenoxy)propanoic acid
Constituent 2
Reference substance name:
Mecoprop-P acid
IUPAC Name:
Mecoprop-P acid
Constituent 3
Reference substance name:
MCPP-P acid
IUPAC Name:
MCPP-P acid
Details on test material:
Purity: 92.7 %

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Oncorhynchus mykiss Walbaum 1792
mean length: 6 cm
mean weight: 1.9 g

Study design

Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d

Test conditions

Test temperature:
16°C
pH:
8.4
Nominal and measured concentrations:
Nominal: 0, 1, 10, 50 and100 mg/L
The measured concentrations averaged 96 % of the range 88.8 - 105.1 %

Results and discussion

Effect concentrations
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
50 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Any other information on results incl. tables

No mortality occured in any test group. Signs or symtoms of toxicity were only observed at the highest concentration of 100 mg/L where slight discoloration was observed on day 2 and 5 of the study. Compared with the control group at the end of the study, the mean body weight at 100 mg/L was statistically significant smaller (<=0.05) and the mean body length at 100 mg/L was statistically significant smaller (<=0.01).

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Remarks:
expected to be valid source
Conclusions:
For Mecoprop-P acid (MCPP-P acid), the hydrolysis product of Mecoprop-P n-octyl ester, a 28 d-NOEC of 50 mg/L was determined.
Executive summary:

Mecoprop-P n-octyl ester hydrolyses rapidly in natural water. Therefore, the hydrolysis product Mecoprop-P acid (MCPP-P acid) was used for further assessment of Mecoprop-P n-octyl ester with respect to toxicity to fish.

 

In a prolonged toxicity test with Mecoprop-P acid (MCPP-P acid) in a flow-through system according to the OECD Guideline 204 a 28 d-NOEC of 50 mg/l was obseved on Oncorhynchus mykiss.