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EC number: 266-358-7 | CAS number: 66423-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable source.
Data source
Reference
- Title:
- The acute toxicity of U46 KV-Fluid (560 g/L of MCPP acid as dimethylamine salt) to Eisenia fetida
- Author:
- Adema & Roza
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 66423-09-4
- Cas Number:
- 66423-09-4
- IUPAC Name:
- 66423-09-4
- Reference substance name:
- Mecoprop-P dimethylamine salt
- IUPAC Name:
- Mecoprop-P dimethylamine salt
- Reference substance name:
- MCPP-P DMA
- IUPAC Name:
- MCPP-P DMA
- Reference substance name:
- R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, dimethylamine salt
- IUPAC Name:
- R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, dimethylamine salt
- Details on test material:
- Purity: not specified
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- average weight at the beginning of the test 0.59 g +/- 0.13 g (n = 40)
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 21°C
- pH:
- 5.7
- Moisture:
- 50 - 55 % %
- Nominal and measured concentrations:
- nominal: 0, 10, 32, 100, 320 and 1000 mg a.i./kg soil
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 988 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Any other information on results incl. tables
For Mecoprop-P dimethylamine salt (MCPP-P DMA) the 14d-LC50 was calculated to be 1764 mg/kg dry soil, corresponding to 988 mg/kg dry soil for Mecoprop-P acid (MCPP-P acid).
Within 14 days of exposure, no worm died at 571 g test substance/kg soil corresponding to 320 mg/kg for Mecoprop-P acid (MCPP-P acid), but they were wetter than the worms of the control and very sluggish.
The NOEC was determined to be 179 mg/kg soil for Mecoprop-P dimethylamine salt (MCPP-P DMA) corresponding to 100 mg/kg soil for Mecoprop-P acid (MCPP-P acid).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Remarks:
- expected to be valid source
- Conclusions:
- For Mecoprop-P acid (MCPP-P acid), the hydrolysis product of Mecoprop-P n-octyl ester, a 14d-LC50 of 988 mg/kg dry soil and a 14d-NOEC of 100 mg/kg dry soil were determined on the earthworm Eisenia fetida.
- Executive summary:
Mecoprop-P n-octyl ester hydrolyses rapidly in natural water. Therefore, the hydrolysis product Mecoprop-P acid (MCPP-P acid) was used for further assessment of Mecoprop-P n-octyl ester with respect to toxicity on terrestrial macroorganisms.
In a test system according to the OECD Guideline 207 for Mecoprop-P acid (MCPP-P acid) a 14d-LC50 of 988 mg/kg dry soil and a 14d-NOEC of 100 mg/kg dry soil was obseved on the earthworm Eisenia fetida.
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