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EC number: 201-857-5 | CAS number: 88-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Increased concentrations of haemoglobin X and Y in the erythrocytes of workers in a chemical plant in Japan
- Author:
- Tomoda A, Tomioka K, Minami M
- Year:
- 1 989
- Bibliographic source:
- British Journal of Industrial Medicine, 46, 502-504
Materials and methods
- Study type:
- human medical data
- Endpoint addressed:
- other: repeated occupational exposure
- Principles of method if other than guideline:
- Blood samples were drawn from 21 production workers handling aromatic compounds such a p-nitrophenol, o-nitrophenol, 4-chlor-2-aminophenol, and 4-chlor-o-aminophenol after their consent.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): o-Nitrophenol
No further data is given.
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- Blood samples were drawn from 21 production workers handling aromatic compounds such a p-nitrophenol, o-nitrophenol, 4-chlor-2-aminophenol, and 4-chlor-o-aminophenol after their consent. 0.1 ml aliquots of bloodwere added to 5 ml distilled water and CO gas was bubbled through the haemolysates. The haemolysates were subjected to isoelectric focusing electrophoresis on polyacrylamide gel plates (LKB - Pharmacia, pH 3.5-9.5) within five hours. After electrophoresis, the gels were treated with a fixing solution and analysed by gel-scanner. The percentages of haemoglobins X, Y, and A, half oxidised haemoglobins such as (α2+ ß3+)2 and (α3+ ß2+)2, methaemoglobin, and haemoglobins E and A2 were estimated by cutting out and weighing the chart paper.
Results and discussion
- Results:
- Half oxidised haemoglobins such as (α2+ ß3+)2 and (α3+ ß2+)2 and methaemoglobin were significantly increased in the erythrocytes. Furthermore, the results showed that two anodic components of haemoglobin (one like haemoglobin X4 and another which migrated to a position between haemoglobins X and A on electrophoresis) were present in large amounts. These unusual haemoglobins are not present in normal controls. From the gel-scanning analysis of the sample, the percentages of each haemoglobin in the total haemoglobin were: Haemoglobin X 7%; haemoglobin Y 22% haemoglobin A + haemoglobin F 57%; (α2+ ß3+)2 + (α3+ ß2+)2 8%; methaemoglobin 3%; and haemoglobin A2 3%.
Haemoglobins X and Y, half oxidised haemoglobins, and methaemoglobin were found to be greatly increased in the erythrocytes of every worker. The appearance of two new anodic components of haemoglobin in the erythrocytes of workers at a chemical plant may result from the oxidation and modification of intracellular haemoglobin A by chemicals absorbed at work. Some of these compounds are likely to become active after being metabolised in the liver.
Applicant's summary and conclusion
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